Mutational and Phylogenetic Analyses of SARS-Cov-2: Bangladesh Perspective

Severe acute respiratory syndrome or SARS-Cov-2 is a global pandemic causing over 6.5 million deaths worldwide. As part of the village, Bangladesh also heavily affected with more than 29,000 in those two years pandemic. Though severity and mortality rate are not so high compared to other countries, faced many difficulties combating mutated newer types Covid-19. The evolution phylogenetic study virus one key areas focus order understand nature virus, its mutation pattern gene prediction. This investigates evolutionary links among older newly emerged SARS‐Cov‐2 variants. In this study, entire genome sequences variants were obtained, aligned using muscle alignment, pairwise comparison was computed, differences, gaps mutations noted. phylogenetics different covid-19 determined variety substitution models. ultrametric metric clustering methods, such as UPGMA neighbor‐joining (NJ), nucleotide models allowed inclusion transitions transversions Kimura 80 findings revealed that Omicron variant forms new monophyletic clade distant from but surprisingly proximity alpha variant, which actually dominant early stage finding indicates omicron might have been there for while, hiding virulence later becomes concern latest wave may pave way researchers find proper insight treatment plan vaccine designing. Pharmaceutical Journal 26(2): 204-211, 2023 (July)